From what it sounds like, 'The Institute' is pretty much the downtown DC or New Vegas of this game.
'First and foremost, the game will take place in Boston, and be kind of a direct sequel to Fallout 3 with a few groups returning. They claimed that Fallout 4 is already in the makings: Since then not much has been heard of about the development of the game until a posting on Motoring Crunch (Redditor GNR_Informant), who claims to be a leaker for Bethesda's public relations department shared this news.
The Fallout 4 release has been highly anticipated from gaming fans but most people were surprised when the game was not discussed at E3 2014. Fallout 4 Release Date, Spoilers & Plot Storyilnes